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« Mai 2018 »

Universitätsklinikum Bonn, AöR
Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin
Direktor: Prof. Dr. A. Hoeft
Sigmund-Freud-Str. 25
53127 Bonn

Tel.: +49 228 287 0

Sie sind hier: Startseite Forschung & Lehre Klinische Studien Durchgeführte Studien

Durchgeführte Studien

Als Klinisches Studienzentrum der Klinik für Anästhesiologie hat unser Team an einer Vielzahl an Studien mitgewirkt. Daraus resultierende Veröffentlichungen sind in Studientitel oder -beschreibung verlinkt.

Randomised Controlled Trials Phase Identifier
MANAGE (Management of myocardial injury After NoncArdiac surGEry) - A large, international, randomized, placebo-controlled trial to assess the impact of dabigatran (a direct thrombin inhibitor) and omeprazole (a proton-pump inhibitor) in patients suffering myocardial injury after noncardiac surgery 3 2011-006056-37 / NCT01661101
POISE-2 ( PeriOperative ISchemic Evaluation-2) : A large, international, placebo-controlled, factorial trial to assess the impact of clonidine and acetyl-salicylic acid (ASA) in patients undergoing noncardiac surgery who are at risk of a perioperative cardiovascular event 3 2009-18173-31 / NCT01082874
OXN2505: An exploratory, double-blind, double-dummy, randomised, 2-period, crossover, Phase IIa study to assess the influence of oxycodone/naloxone prolonged-release tablets (OXN PR) and oxycodone prolonged-release tablets (OxyPR) on intestinal microbiota and other gastrointestinal parameters in subjects suffering from non-malignant pain requiring an equivalent of 20 – 50 mg oxycodone PR per day  2a 2012-001772-11 / NCT01915147
PROVHILO (PROtective Ventilation using HIgh versus LOw levels of positive end-expiratory pressure (PEEP) during general Anesthesia for open abdominal surgery) - A randomized controlled trial   NCT01441791
MDCO-2010 - A Phase II, double-blind, parallel group, dose-selection study to compare antifibrinolytic MDCO-2010 vs. placebo and tranexamic acid in reducing blood loss in patients undergoing primary cardiac surgery.  2b  2011-004666-15 / NCT01530399
VNK115640 - A Multicenter, Randomized, Single-blind, Active-controlled, Parallel Group, Phase II Study to Evaluate the Efficacy, Safety, and Tolerability of a Single Intravenous (6 mg, 12 mg, 18 mg, 24 mg or 36 mg) Dose of the Neurokinin-1 Receptor Antagonist, Vestipitant (GW597599), Compared with a Single 4 mg Intravenous Ondansetron Hydrochloride Dose for the Treatment of Breakthrough Post-Operative Nausea and Vomiting after Failed Prophylaxis with an Ondansetron-
Containing Regimen in Patients Undergoing Non-Emergency Surgical Procedures.
2011-005216-28 / NCT01507194
Sugammadex - Reversal of neuromuscular blockade with sugammadex or usual care in hip/knee fracture surgery or joint replacement  3  2011-001201-27 / NCT01422304
RIPHeart Study ( Remote Ischaemic Preconditioning for Heart surgery) - The study design for a multi-center randomized double-blinded controlled clinical trial  3 DFG: ME3559/1 / NCT01067703
Sunlight - A randomized, safety-assessor blinded trial comparing 4.0 sugammadex with placebo in adult subjects scheduled for surgery requiring profound neuromuscular blockade  3 2008-002518-23 / NCT00758485
CONSERV-2 (Clinical Outcomes aNd Safety trial to investigate Ecallantide´s Effect on Reducing surgical blood loss Volume) :  A Phase 2 Randomized, controlled Study in subjects exposed to cardio-pulmonary bypass during cardiac surgery at high risk for bleeding  2  2008-008354-23 / NCT00888940
MEND-CABG  II (Efficacy and Safety of Pyridoxal 5′-Phosphate (MC-1) in High-Risk Patients Undergoing Coronary Artery Bypass Graft Surgery)  2  2006-006034-18 / NCT00157716
A Double-Blind Multicenter Study of the Safety and Efficacy of Parecoxib Sodium/Valdecoxib and Placebo/Valdecoxib Compared to Placebo for Treatment of Post-Surgical Pain in Patients Who Have Coronary Bypass Graft Via Median Sternotomy 3
RED-CABG ( Reduction in Cardiovascular Events by AcaDesine in Subjects Undergoing CABG) :  Effect of Acadesine on Clinically Significant adeverse Cardiovascular and cerebrovascular Events in High-Risk Subjects undergoing Coronary Artery Bypass Graft (CABG)  3   2008-00488-16 / NCT00872001
E5564 - A multicenter, randomized, double-blind, placebo-controlled, parallel study of E5564, a lipid antagonist, in patients undergoing coronary artery bypass grafting and/or valve surgery with cardiopulmonary bypass  3   E5564-A001-204
A randomized, controlled,  open-label trial to evaluate the effect of long-term treatment with oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine on nausea, emesis and constipation  4  
NTL 06 - A phase 3 comparison of Neutralase TM  to protamine in patients undergoing primary coronary artery bypass graft surgery
 3  Protocol NTL06
EXPEDITION (NA+/ H+ EXchange inhibition to Prevent coronary Events in acute cadiac conDITIONs) - A double-blind, placebo-controlled, multinational trial to investigate the effect of IV treatment with the NA+/H* exchange inhibitor cariporide (HOE642) on all-cause mortality and non-fatal myocardial infarction in patients at risk of myocardial necrosis during and after artery bypass graft surgery  3 HOE642A/3002


Observatory Studies
POPULAR (POstaneasthesia PULmonary complications After use of muscle Relaxants in europe) NCT: 01865513
ISOS (International Surgical Outcomes
Study) - An international observational cohort study of complications following elective surgery
BONNCORE (BONN Cerebral Oxygen Risk Evaluation) -Präoperative Risikoevaluation: Stellenwert der zerebralen Oxygenierung bei nicht.kardiochirurgischen Patienten mit schwerer Allgemeinerkrankung  
ETPOS (European Transfusion Practice and Outcome Study) - A Multi-central evaluation of standard of transfusion care and clinical outcome for elective surgical patients - observational NCT01604083
EMMAperiop (Evaluation des Managements von ambulanten Medikamenten für die Anästhesie in der perioperativen) -Prospektive multizentrische Beobachtungsstudie des Effekts des perioperativen Managements von RAAS Modulatoren vor elektiven operativen Eingriffen.
OBTAIN (Occurrence of Bleeding and Thrombosis during Antiplatelet therapy in Non-cardiac surgery) - A prospective oberservational study NCT01358422 
PERISCOPE (Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe) - multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric in-hospital surgical procedure under general or regional anaesthesia during a continued 7-day period of recruitment NCT01346709
EuSOS (European Surgical Outcomes Study) - multi-centre, international cohort study of peri-operative care and clinical outcomes for patients undergoing non-cardiac surgery NCT01203605
Euro-STAT (European registry for Studying the Treatment of Acute hyperTension) -  Characteristics, practice patterns, and outcomes in patients with acute hypertension  
A controlled, prospective, observational cohort study to examine the technique of opioid rotation to oral sustained-release hydromorphone for controlling pain and symptoms in outpatients with cancer pain  
PBM (Patient Blood Management) - Safety and Effectiveness of a Patient Blood Management Program in Surgical Patients - prospective observational NCT01820949